Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $155 $775,000 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $39.15 $195,750 Option
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Non-Qualified Stock Option (Right to Buy) 10,000 $72.64 $726,400 Sale
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 2,615 $141.04 $368,820 Sale
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 7,185 $140.55 $1,009,852 Sale
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 200 $138.62 $27,724 Option
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 10,000 $72.64 $726,400 Option
GRYSKA DAVID W director director
Non-Qualified Stock Option (right to buy) 8,750 $36.7 $321,125 Option
GRYSKA DAVID W director director
Common Stock 8,750 $36.7 $321,125 Sale
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 783 $138.52 $108,461 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Non-Qualified Stock Option (right to buy) 5,000 $39.15 $195,750 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $135.03 $675,135 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $39.15 $195,750 Option
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Non-Qualified Stock Option (right to buy) 10,000 $72.64 $726,400 Sale
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 10,000 $135 $1,350,000 Option
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 10,000 $72.64 $726,400 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 578 $130.71 $75,548 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Non-Qualified Stock Option (right to buy) 4,525 $39.15 $177,154 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 4,525 $135 $610,875 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 4,525 $39.15 $177,154 Option
DANSEY ROGER D officer: President R&D & CMO officer: President R&D & CMO
Non-Qualified Stock Option (right to buy) 7,500 $72.64 $544,800 Sale
DANSEY ROGER D officer: President R&D & CMO officer: President R&D & CMO
Common Stock 7,500 $135 $1,012,500 Option
DANSEY ROGER D officer: President R&D & CMO officer: President R&D & CMO
Common Stock 7,500 $72.64 $544,800 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Non-Qualified Stock Option (right to buy) 475 $39.15 $18,596 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 475 $135 $64,125 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 475 $39.15 $18,596 Option
DANSEY ROGER D officer: President R&D & CMO officer: President R&D & CMO
Non-Qualified Stock Option (right to buy) 2,500 $72.64 $181,600 Sale
DANSEY ROGER D officer: President R&D & CMO officer: President R&D & CMO
Common Stock 2,500 $135 $337,500 Option
DANSEY ROGER D officer: President R&D & CMO officer: President R&D & CMO
Common Stock 2,500 $72.64 $181,600 Sale
ROMP CHARLES R officer: EVP, Commercial U.S. officer: EVP, Commercial U.S.
Common Stock 1,129 $127.63 $144,094 Option
DANSEY ROGER D officer: President, Research and Develo officer: President, Research an..
Non-Qualified Stock Option (right to buy) 9,403 $77.45 $728,262 Option
DANSEY ROGER D officer: President, Research and Develo officer: President, Research an..
Non-Qualified Stock Option (right to buy) 597 $72.64 $43,366 Sale
DANSEY ROGER D officer: President, Research and Develo officer: President, Research an..
Common Stock 9,403 $135 $1,269,405 Option
DANSEY ROGER D officer: President, Research and Develo officer: President, Research an..
Common Stock 9,403 $77.45 $728,262 Option
DANSEY ROGER D officer: President, Research and Develo officer: President, Research an..
Common Stock 597 $72.64 $43,366 Option
SIMONIAN NANCY A director director
Non-Qualified Stock Option (right to buy) 8,750 $36.7 $321,125 Option
SIMONIAN NANCY A director director
Common Stock 8,750 $36.7 $321,125 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Non-Qualified Stock Option (right to buy) 8,333 $34.2 $284,989 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 8,333 $131.05 $1,092,056 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 8,333 $34.2 $284,989 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Incentive Stock Option (right to buy) 1,301 $76.86 $99,995 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 1,301 $76.86 $99,995 Sale
GRYSKA DAVID W director director
Common Stock 7,500 $129.1 $968,220 Option
DANSEY ROGER D officer: Interim CEO & CMO officer: Interim CEO & CMO
Common Stock 3,189 $76.86 $245,107 Option
DANSEY ROGER D officer: Interim CEO & CMO officer: Interim CEO & CMO
Common Stock 4,607 $77.45 $356,812 Sale
DANSEY ROGER D officer: Interim CEO & CMO officer: Interim CEO & CMO
Common Stock 2,204 $135 $297,540 Option
DANSEY ROGER D officer: Interim CEO & CMO officer: Interim CEO & CMO
Common Stock 2,204 $65.11 $143,502 Option
DANSEY ROGER D officer: Interim CEO & CMO officer: Interim CEO & CMO
Non-Qualified Stock Option (right to buy) 4,607 $77.45 $356,812 Option
DANSEY ROGER D officer: Interim CEO & CMO officer: Interim CEO & CMO
Non-Qualified Stock Option (right to buy) 3,189 $76.86 $245,107 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,064 $154.42 $318,713