Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 13,431 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 112,500 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 3,105 N/A N/A Purchase
LIPPMAN MARC E director director
Common Stock 20,000 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 150 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 5,416 N/A N/A Option
BERGER FRANKLIN M director director
Common Stock 17,000 N/A N/A Option
BERGER FRANKLIN M director director
Non-Qualified Stock Option (right to buy) 17,000 N/A N/A Purchase
BERGER FRANKLIN M director director
Common Stock 5,000 N/A N/A Purchase
LIPPMAN MARC E director director
Common Stock 11,075 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 9,627 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 348,739 N/A N/A Sale
REYNOLDS THOMAS C officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,797 N/A N/A Option
REYNOLDS THOMAS C officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 23,203 N/A N/A Option
REYNOLDS THOMAS C officer: Chief Medical Officer officer: Chief Medical Officer
Non-Qualified Stock Option (right to buy) 23,203 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 5,879 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 212,970 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 8,447 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 306,022 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 10,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Incentive Stock Option (right to buy) 10,000 N/A N/A Purchase
BERGER FRANKLIN M director director
Common Stock 11,500 N/A N/A Purchase
BERGER FRANKLIN M director director
Common Stock 5,000 N/A N/A Purchase
BERGER FRANKLIN M director director
Common Stock 8,000 N/A N/A Option
GRYSKA DAVID W director director
Non-Qualified Stock Option (right to buy) 4,000 N/A N/A Option
GRYSKA DAVID W director director
Common Stock 4,000 N/A N/A Option
BERGER FRANKLIN M director director
Non-Qualified Stock Option (right to buy) 10,000 N/A N/A Option
BERGER FRANKLIN M director director
Common Stock 10,000 N/A N/A Option
HOTH DANIEL FLOYD JR director director
Common Stock 10,405 N/A N/A Option
HOTH DANIEL FLOYD JR director director
Non-Qualified Stock Option (right to buy) 10,405 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Incentive Stock Option (right to buy) 6,985 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 6,985 N/A N/A Option
BERGER FRANKLIN M director director
Common Stock 5,000 N/A N/A Option
BERGER FRANKLIN M director director
Non-Qualified Stock Option (right to buy) 5,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 10,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Incentive Stock Option (right to buy) 10,000 N/A N/A Purchase
AKKARAJU SRINIVAS director director
Common Stock 4,905 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 43,134 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 798 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 1,562,664 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 273,404 N/A N/A Sale
REYNOLDS THOMAS C officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 25,000 N/A N/A Option
REYNOLDS THOMAS C officer: Chief Medical Officer officer: Chief Medical Officer
Non-Qualified Stock Option (right to buy) 25,000 N/A N/A Option
REYNOLDS THOMAS C officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 25,000 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Non-Qualified Stock Option (right to buy) 33,734 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 33,734 N/A N/A Sale
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 21,989 N/A N/A Option
BERGER FRANKLIN M director director
Non-Qualified Stock Option (right to buy) 5,000 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Non-Qualified Stock Option (right to buy) 19,266 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 19,266 N/A N/A