Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,673 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 17,793 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 52,736 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 70,757 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 23,873 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 2,245 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 189 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 583 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 3,922 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 123,528 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 330 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 46,306 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Comm on Stock 103 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,219 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 181 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 14,396 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 38,404 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4,302 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 55 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 11,475 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 31 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 362 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 103 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 38,112 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 8,601 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 723 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,212 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 338 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 20,242 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 89,682 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Comm on Stock 238 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 2,852 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 97 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 70 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 5,810 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 819 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 25,744 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 95,716 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 3,045 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 259 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,915 N/A N/A Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 2,084 N/A N/A Purchase
BERGER FRANKLIN M director director
Common Stock 528 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Comm on Stock 160 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 18,869 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 65,139 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 1,344 N/A N/A Purchase
BAKER BIOTECH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 560,047 N/A N/A Purchase
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 1,933,423 N/A N/A