Purchase
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 61,872 N/A N/A Purchase
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 4,747 N/A N/A Purchase
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 39,911 N/A N/A Option
GRYSKA DAVID W director director
Common Stock 6,000 N/A N/A Option
GRYSKA DAVID W director director
Non-Qualified Stock Option (right to buy) 6,000 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 5,000 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Incentive Stock Option (right to buy) 5,000 N/A N/A Option
LIPPMAN MARC E director director
Common Stock 20,000 N/A N/A Option
LIPPMAN MARC E director director
Non-Qualified Stock Option (right to buy) 20,000 N/A N/A Sale
JP MORGAN PARTNERS BHCA LP 10 percent owner 10 percent owner
Class A Common Stock 21,092 N/A N/A Sale
AKKARAJU SRINIVAS director director
Class A Common Stock 20,960 N/A N/A Option
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Non-Qualified Stock Option (right to buy) 15,000 N/A N/A Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,700 N/A N/A Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Non-Qualified Stock Option (right to buy) 32,250 N/A N/A Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 32,250 N/A N/A Option
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Common Stock 15,000 N/A N/A Sale
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Common Stock 5,500 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Incentive Stock Option (right to buy) 15,212 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 20,629 N/A N/A Sale
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 4,700 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Non-Qualified Stock Option (right to buy) 44,600 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 35,500 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Non-Qualified Stock Option (right to buy) 55,400 N/A N/A Option
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 50,000 N/A N/A Sale
DOBMEIER ERIC officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 20,000 N/A N/A Purchase
LIPPMAN MARC E director director
Common Stock 2,000 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 74,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 95,700 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 63,700 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Incentive Stock Option (right to buy) 50,000 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 11,332 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 71,300 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 5,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 71,300 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 31,668 N/A N/A Sale
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Common Stock 3,000 N/A N/A Option
SIEGALL CLAY B director, officer: President and CEO director, officer: President an..
Non-Qualified Stock Option (right to buy) 31,668 N/A N/A Option
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Common Stock 24,000 N/A N/A Option
TRAILSMITH PAMELA A officer: Chief Scientific Officer officer: Chief Scientific Officer
Non-Qualified Stock Option (right to buy) 59,891 N/A N/A Sale
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Common Stock 11,500 N/A N/A Sale
TRAILSMITH PAMELA A officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 38,891 N/A N/A Option
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Non-Qualified Stock Option (right to buy) 25,000 N/A N/A Option
TRAILSMITH PAMELA A officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 59,891 N/A N/A Option
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Non-Qualified Stock Option (right to buy) 25,000 N/A N/A Option
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Common Stock 15,000 N/A N/A Sale
ROSENBERG MORRIS officer: EVP, Process Sciences officer: EVP, Process Sciences
Common Stock 10,000 N/A N/A Sale
BAKER BROS. CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 149,930 N/A N/A Sale
BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC director, 1.. director, 10 percent owner
Common Stock 1,599,792 N/A N/A Sale
14159 CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 19,561 N/A N/A Sale
BAKER / TISCH CAPITAL (GP), LLC director, 10 percent owner director, 10 percent owner
Common Stock 102,935 N/A N/A