Option
BAKER BROS. ADVISORS LP director, 10 percent owner: director, 10 percent owner:
Non-Qualified Stock Option (right to buy) 8,750 $36.7 $321,125 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $39.15 $195,750 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $205.86 $1,029,310 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Non-Qualified Stock Option (right to buy) 5,000 $39.15 $195,750 Option
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 10,000 $72.64 $726,400 Sale
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 10,000 $205.95 $2,059,490 Option
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Non-Qualified Stock Option (right to buy) 10,000 $72.64 $726,400 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 14,980 $46.37 $694,623 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 55,344 $204.44 $11,314,527 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 40,364 $46.37 $1,871,679 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Non-Qualified Stock Option (right to buy) 14,980 $46.37 $694,623 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Non-Qualified Stock Option (right to buy) 40,364 $46.37 $1,871,679 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 174 $205.86 $35,819 Sale
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 243 $205.86 $50,023 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 243 $205.86 $50,023 Sale
ROMP CHARLES R officer: EVP, Commercial U.S. officer: EVP, Commercial U.S.
Common Stock 133 $205.86 $27,379 Sale
DANSEY ROGER D officer: President, R&D & CMO officer: President, R&D & CMO
Common Stock 333 $205.86 $68,550 Option
WELCH DANIEL G director director
Common Stock 995 $38.82 $38,626 Sale
WELCH DANIEL G director director
Common Stock 17,525 $201.74 $3,535,546 Option
WELCH DANIEL G director director
Common Stock 5,680 $66.6 $378,288 Option
WELCH DANIEL G director director
Common Stock 3,575 $66.6 $238,095 Option
WELCH DANIEL G director director
Common Stock 5 $66.6 $333 Option
WELCH DANIEL G director director
Common Stock 7,158 $56.77 $406,360 Option
WELCH DANIEL G director director
Common Stock 112 $56.77 $6,358 Sale
WELCH DANIEL G director director
Common Stock 817 $200.45 $163,768 Sale
WELCH DANIEL G director director
Common Stock 851 $201.51 $171,485 Sale
WELCH DANIEL G director director
Common Stock 1,082 $202.54 $219,148 Sale
WELCH DANIEL G director director
Common Stock 3,124 $200.45 $626,206 Sale
WELCH DANIEL G director director
Common Stock 3,317 $201.51 $668,409 Sale
WELCH DANIEL G director director
Common Stock 4,284 $202.54 $867,681 Option
WELCH DANIEL G director director
Non-Qualified Stock Option (right to buy) 10,255 $52.71 $540,541 Option
WELCH DANIEL G director director
Non-Qualified Stock Option (right to buy) 7,270 $56.77 $412,718 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $39.15 $195,750 Sale
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 5,000 $199.9 $999,500 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Non-Qualified Stock Option (right to buy) 5,000 $39.15 $195,750 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Non-Qualified Stock Option (right to buy) 42,793 $45.3 $1,938,523 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 6,082 $177.37 $1,078,764 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 26,449 $176.71 $4,673,803 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 10,262 $175.89 $1,804,983 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 42,793 $45.3 $1,938,523 Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Non-Qualified Stock Option (right to buy) 2,691 $41.04 $110,439 Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Non-Qualified Stock Option (right to buy) 13,524 $41.04 $555,025 Sale
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 2,691 $177.92 $478,783 Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 2,691 $41.04 $110,439 Option
HIMES VAUGHN B officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 13,524 $41.04 $555,025 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 20,000 $182.53 $3,650,600 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Non-Qualified Stock Option (right to buy) 39,946 $39.15 $1,563,886 Sale
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 39,946 $160 $6,391,400 Option
SIMPSON TODD E officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 39,946 $39.15 $1,563,886 Option
LIU JEAN I officer: Chief Legal Officer officer: Chief Legal Officer
Non-Qualified Stock Option (right to buy) 5,000 $39.15 $195,750