Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   1,003  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   3,791  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   1,768  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   3,292  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   1,003  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   2,541  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   3,292  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   1,003  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   2,541  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   4,667  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   3,292  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,582  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,582  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Restricted Stock Units   1,768  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Restricted Stock Units   1,768  N/A   N/A      Option 
    DESANTIS ROBERT  officer: Executive VP & GM IA&E  officer: Executive VP & GM IA&E 
  Restricted Stock Units   3,166  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,582  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   4,667  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   21,000  $168.41    $3,536,610     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   12,487  $800    $9,989,600     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   21,000  $168.41    $3,536,610     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   11,020  $762.14    $8,398,761     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   14,000  $168.41    $2,357,740     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   9,375  $148.03    $1,387,781     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   9,375  $148.03    $1,387,781     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   9,375  $148.03    $1,387,781     Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Non-Qualified Stock Option (right to buy)   1,250  $170.76    $213,446     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   269  $625.59    $168,283     Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   1,250  $170.76    $213,446     Option 
    LEVY ALAN J  director  director 
  Common Stock   2,500  $161.27    $403,168     Option 
    LEVY ALAN J  director  director 
  Non-Qualified Stock Option (right to buy)   2,500  $161.27    $403,168     Sale 
    LEVY ALAN J  director  director 
  Common Stock   2,500  $161.27    $403,168     Sale 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   1,652  $462.62    $764,245     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   18  $754.48    $13,581     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   330  $651.37    $214,951     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   2,900  $758.41    $2,199,395     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   14,000  $168.41    $2,357,740     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   11,114  $761.76    $8,466,234     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   14,000  $168.41    $2,357,740     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   341  $670.18    $228,532     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   36  $778    $28,008     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   312  $670.18    $209,097     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   6,000  $127.91    $767,460     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   6,000  $127.91    $767,460     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   6,000  $127.91    $767,460     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   875  $238.91    $209,049     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   875  $238.91    $209,049     Sale 
    LEVY ALAN J  director  director 
  Common Stock   1,800  $193.08    $347,544     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   646  $537.24    $347,055     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   875  $238.91    $209,049