Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   7,500  $107.27    $804,525     Sale 
    LOOP FLOYD D MD  director  director 
  Common Stock   2,125  $483.8    $1,028,075     Option 
    LOOP FLOYD D MD  director  director 
  Common Stock   2,125  $483.8    $1,028,075     Option 
    LOOP FLOYD D MD  director  director 
  Non-Qualified Stock Option (right to buy)   2,125  $483.8    $1,028,075     Sale 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   15,000  $334.3    $5,014,500     Option 
    LOOP FLOYD D MD  director  director 
  Common Stock   15,185  $361.71    $5,492,597     Sale 
    LOOP FLOYD D MD  director  director 
  Common Stock   4,767  $475    $2,264,325     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   2,500  $107.27    $268,175     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Non-Qualified Stock Option (right to buy)   15,000  $334.3    $5,014,500     Option 
    LOOP FLOYD D MD  director  director 
  Non-Qualified Stock Option (right to buy)   4,700  $475    $2,232,500     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,500  $107.27    $268,175     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,500  $107.27    $268,175     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   15,000  $334.3    $5,014,500     Sale 
    LOOP FLOYD D MD  director  director 
  Common Stock   1,742  $480.05    $836,242     Option 
    LOOP FLOYD D MD  director  director 
  Common Stock   5,003  $185.73    $929,222     Option 
    LOOP FLOYD D MD  director  director 
  Non-Qualified Stock Option (right to buy)   5,003  $185.73    $929,222     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   6,626  $403.18    $2,671,484     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   6,000  $472.06    $2,832,384     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   12,626  $426.14    $5,380,482     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   4,105  $107.27    $440,343     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   4,105  $107.27    $440,343     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   4,105  $107.27    $440,343     Sale 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   5,000  $465.62    $2,328,100     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Non-Qualified Stock Option (right to buy)   9,167  $286.45    $2,625,841     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   9,167  $286.45    $2,625,841     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   2,000  $107.27    $214,540     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   2,000  $107.27    $214,540     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   2,000  $107.27    $214,540     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   1,000  $107.27    $107,270     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   1,000  $107.27    $107,270     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   1,000  $107.27    $107,270     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   500  $107.27    $53,635     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   500  $107.27    $53,635     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   582  $320.26    $186,393     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   66  $414    $27,324     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   743  $18.5    $13,746     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   743  $18.5    $13,746     Option 
    SMITH LONNIE M  director  director 
  Non-Qualified Stock Option (right to buy)   25,000  $324.35    $8,108,750     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   13,750  $107.27    $1,474,963     Option 
    SMITH LONNIE M  director  director 
  Common Stock   25,000  $324.35    $8,108,750     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   3,344  $404.42    $1,352,391     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,000  $553    $553,000     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   3,344  $404.42    $1,352,391     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Non-Qualified Stock Option (right to buy)   8,464  $303.27    $2,566,877     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   8,000  $420.45    $3,363,616     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   3,200  $574.12    $1,837,190     Sale 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   8,464  $303.27    $2,566,877     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   8,000  $420.45    $3,363,616     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   8,464  $303.27    $2,566,877     Sale 
    HALVORSON ERIC H  director  director 
  Common Stock   1,500  $365.98    $548,970