Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $252.51    $1,515,060     Option 
    RUBASH MARK J  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    NACHTSHEIM JAMI K  director  director 
  Common Stock   555  N/A   N/A      Option 
    NACHTSHEIM JAMI K  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Common Stock   555  N/A   N/A      Option 
    LADD AMY L  director  director 
  Common Stock   555  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Common Stock   555  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    KANIA DON R  director  director 
  Common Stock   555  N/A   N/A      Option 
    REED MONICA P  director  director 
  Common Stock   555  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Common Stock   555  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Restricted Stock Units   753  N/A   N/A      Option 
    BEERY JOSEPH C  director  director 
  Common Stock   555  N/A   N/A      Option 
    BEERY JOSEPH C  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Common Stock   555  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    KANIA DON R  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    REED MONICA P  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    LADD AMY L  director  director 
  Restricted Stock Units   555  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Common Stock   753  N/A   N/A      Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,000  $289.96    $579,920     Option 
    SAMATH JAMIE  officer: Chief Financial Officer  officer: Chief Financial Officer 
  Restricted Stock Units   1,257  N/A   N/A      Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   2,256  N/A   N/A      Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   1,713  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   1,128  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Restricted Stock Units   1,467  N/A   N/A      Option 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Common Stock   852  N/A   N/A      Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   2,175  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive Vice President Glob  officer: Executive Vice Preside.. 
  Common Stock   2,256  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive Vice President Glob  officer: Executive Vice Preside.. 
  Restricted Stock Units   1,713  N/A   N/A      Option 
    ROSA DAVID J.  officer: Executive Vice President and C  officer: Executive Vice Preside.. 
  Common Stock   2,256  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive Vice President Glob  officer: Executive Vice Preside.. 
  Restricted Stock Units   2,256  N/A   N/A      Option 
    CHARLTON HENRY L  officer: Senior Vice President & Chief  officer: Senior Vice President .. 
  Common Stock   1,449  N/A   N/A      Option 
    CHARLTON HENRY L  officer: Senior Vice President & Chief  officer: Senior Vice President .. 
  Restricted Stock Units   1,449  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Restricted Stock Units   1,128  N/A   N/A      Option 
    SAMATH JAMIE  officer: Chief Financial Officer  officer: Chief Financial Officer 
  Common Stock   1,257  N/A   N/A      Option 
    SAMATH JAMIE  officer: Chief Financial Officer  officer: Chief Financial Officer 
  Restricted Stock Units   1,284  N/A   N/A      Option 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Restricted Stock Units   609  N/A   N/A      Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Restricted Stock Units   2,175  N/A   N/A      Option 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Restricted Stock Units   852  N/A   N/A      Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,256  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   3,867  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   3,867  N/A   N/A      Option 
    CHARLTON HENRY L  officer: Senior Vice President & Chief  officer: Senior Vice President .. 
  Restricted Stock Units   1,284  N/A   N/A      Option 
    ROSA DAVID J.  officer: Executive Vice President and C  officer: Executive Vice Preside.. 
  Restricted Stock Units   1,713  N/A   N/A      Option 
    ROSA DAVID J.  officer: Executive Vice President and C  officer: Executive Vice Preside.. 
  Restricted Stock Units   2,256  N/A   N/A      Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Restricted Stock Units   1,590  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   3,030  N/A   N/A      Option 
    CHARLTON HENRY L  officer: Senior Vice President & Chief  officer: Senior Vice President .. 
  Common Stock   1,284  N/A   N/A