Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   2,193  $480.2    $1,053,068     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   562  $557.48    $313,304     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   2,652  $428.72    $1,136,960     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   350  $161.27    $56,443     Option 
    RUBASH MARK J  director  director 
  Common Stock   350  $161.27    $56,443     Sale 
    RUBASH MARK J  director  director 
  Common Stock   350  $161.27    $56,443     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   150  $123.77    $18,566     Sale 
    RUBASH MARK J  director  director 
  Common Stock   150  $123.77    $18,566     Option 
    RUBASH MARK J  director  director 
  Common Stock   150  $123.77    $18,566     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   1,125  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   1,125  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   60,000  $35.76    $2,145,420     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   245  $521.19    $127,690     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   35,672  $520.24    $18,557,859     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   60,000  $35.76    $2,145,420     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   8,250  $111.43    $919,322     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   8,250  $111.43    $919,322     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   8,250  $111.43    $919,322     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   714  $453.07    $323,491     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   3,000  $121.99    $365,979     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   431  $406.11    $175,035     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   56,000  $523.37    $29,308,776     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   450  $347.4    $156,329     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   178  $523.5    $93,184     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   20,000  $111.43    $2,228,660     Sale 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   20,000  $111.43    $2,228,660     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Non-Qualified Stock Option (right to buy)   20,000  $111.43    $2,228,660     Sale 
    JOHNSON AMAL M  director  director 
  Common Stock   3,000  $121.99    $365,979     Sale 
    BARRATT CRAIG H  director  director 
  Common Stock   2,500  $193.08    $482,700     Option 
    BARRATT CRAIG H  director  director 
  Common Stock   2,500  $193.08    $482,700     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   262  $171.33    $44,889     Option 
    BARRATT CRAIG H  director  director 
  Non-Qualified Stock Option (right to buy)   2,500  $193.08    $482,700     Option 
    JOHNSON AMAL M  director  director 
  Non-Qualified Stock Option (right to buy)   3,000  $121.99    $365,979     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   712  $288.71    $205,562     Option 
    FRIEDMAN MICHAEL A  director  director 
  Common Stock   975  N/A   N/A      Option 
    FRIEDMAN MICHAEL A  director  director 
  Restricted Stock Units   975  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   1,500  $113.73    $170,595     Sale 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   1,500  $113.73    $170,595     Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Non-Qualified Stock Option (right to buy)   6,000  $113.73    $682,380     Sale 
    RUBASH MARK J  director  director 
  Common Stock   1,000  $193.08    $193,080     Option 
    RUBASH MARK J  director  director 
  Common Stock   1,000  $193.08    $193,080     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   1,000  $193.08    $193,080     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   1,630  $480    $782,400     Sale 
    BARRATT CRAIG H  director  director 
  Common Stock   2,500  $193.08    $482,700     Option 
    BARRATT CRAIG H  director  director 
  Common Stock   2,500  $193.08    $482,700     Sale 
    RUBASH MARK J  director  director 
  Common Stock   1,000  $193.08    $193,080     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   7,703  $480    $3,697,440     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   1,787  $317.26    $566,945     Option 
    RUBASH MARK J  director  director 
  Common Stock   1,000  $193.08    $193,080     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,890  $390.18    $737,448