Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Restricted Stock Units   2,124  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   3,750  N/A   N/A      Option 
    CHARLTON HENRY L  officer: Senior Vice President & Chief  officer: Senior Vice President .. 
  Common Stock   1,311  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   3,750  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP Chief Strategy & Growth Of  officer: EVP Chief Strategy & G.. 
  Common Stock   2,250  N/A   N/A      Sale 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Common Stock   1,307  $246.09    $321,640     Sale 
    MOHR MARSHALL  officer: Executive VP Global Business S  officer: Executive VP Global Bu.. 
  Common Stock   33,249  $245.61    $8,166,387     Option 
    MOHR MARSHALL  officer: Executive VP Global Business S  officer: Executive VP Global Bu.. 
  Non-Qualified Stock Option (right to buy)   54,000  $63.25    $3,415,284     Option 
    MOHR MARSHALL  officer: Executive VP Global Business S  officer: Executive VP Global Bu.. 
  Common Stock   54,000  $63.25    $3,415,284     Option 
    ROSA DAVID J.  officer: EVP Chief Strategy & Growth Of  officer: EVP Chief Strategy & G.. 
  Non-Qualified Stock Option (right to buy)   54,000  $63.25    $3,415,284     Sale 
    ROSA DAVID J.  officer: EVP Chief Strategy & Growth Of  officer: EVP Chief Strategy & G.. 
  Common Stock   45,025  $250.53    $11,280,023     Option 
    ROSA DAVID J.  officer: EVP Chief Strategy & Growth Of  officer: EVP Chief Strategy & G.. 
  Common Stock   54,000  $63.25    $3,415,284     Sale 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   816  $250    $204,000     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Non-Qualified Stock Option (right to buy)   816  $177.99    $145,237     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Non-Qualified Stock Option (right to buy)   813  $179.7    $146,096     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   816  $177.99    $145,237     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   813  $179.7    $146,096     Option 
    JOHNSON AMAL M  director  director 
  Non-Qualified Stock Option (right to buy)   6,375  $53.76    $342,695     Sale 
    JOHNSON AMAL M  director  director 
  Common Stock   6,375  $239.36    $1,525,907     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   6,375  $53.76    $342,695     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   6,000  $174.26    $1,045,542     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $250.06    $1,500,384     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,000  $166.62    $333,246     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   2,000  $166.62    $333,246     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $174.26    $1,045,542     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $209.78    $1,258,680     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   6,000  $174.26    $1,045,542     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,000  $166.62    $333,246     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   44,203  $210.84    $9,319,628     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $174.26    $1,045,542     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   67,500  $63.25    $4,269,105     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   67,500  $63.25    $4,269,105     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   2,000  $166.62    $333,246     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   6,375  $53.76    $342,695     Sale 
    JOHNSON AMAL M  director  director 
  Common Stock   6,375  $210.76    $1,343,582     Option 
    JOHNSON AMAL M  director  director 
  Non-Qualified Stock Option (right to buy)   6,375  $53.76    $342,695     Sale 
    LADD AMY L  director  director 
  Common Stock   600  $237.03    $142,218     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   6,375  $53.76    $342,695     Sale 
    JOHNSON AMAL M  director  director 
  Common Stock   6,375  $238.04    $1,517,486     Option 
    JOHNSON AMAL M  director  director 
  Non-Qualified Stock Option (right to buy)   6,375  $53.76    $342,695     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   9,000  $225    $2,025,000     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   9,000  $139.52    $1,255,680     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   9,000  $139.52    $1,255,680     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   126,000  $57.48    $7,242,354     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   79,412  $216.3    $17,177,054     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   126,000  $57.48    $7,242,354     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   363  N/A   N/A      Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Restricted Stock Units   363  N/A   N/A      Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   6,000  $139.52    $837,120     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $139.52    $837,120