Sale 
    LEVY ALAN J  director  director 
  Common Stock   5,000  $288.5    $1,442,500     Option 
    LEVY ALAN J  director  director 
  Common Stock   5,000  $288.5    $1,442,500     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   2,500  $341.19    $852,975     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   2,500  $341.19    $852,975     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   2,500  $341.19    $852,975     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   830  $303.27    $251,714     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   830  $303.27    $251,714     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   884  $437.3    $386,570     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   2,500  $107.27    $268,175     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,500  $107.27    $268,175     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,500  $107.27    $268,175     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   766  $506.16    $387,716     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   766  $506.16    $387,716     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,491  $506.16    $754,680     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   5,000  $341.19    $1,705,950     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   5,000  $341.19    $1,705,950     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   5,530  $441.98    $2,444,122     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   417  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   261  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   500  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   521  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   521  N/A   N/A      Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Restricted Stock Units   417  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   261  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   625  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   521  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   521  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Restricted Stock Units   500  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   521  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Restricted Stock Units   521  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   417  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   625  N/A   N/A      Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   417  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   759  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   244  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   867  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Restricted Stock Units   569  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   434  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   244  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Restricted Stock Units   759  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   569  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   867  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   759  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   705  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   759  N/A   N/A      Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   434  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   434  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   705  N/A   N/A      Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Restricted Stock Units   434  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   2,000  $341.19    $682,380