Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   4,667  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   1,005  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   3,292  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   1,770  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   3,292  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   1,770  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,584  N/A   N/A      Sale 
    SMITH LONNIE M  director  director 
  Common Stock   28,200  $600.72    $16,940,332     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   333  $499.87    $166,457     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   1,492  $566.62    $845,402     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   7,800  $600.3    $4,682,363     Sale 
    LEONARD KEITH R  director  director 
  Common Stock   1,545  $271.48    $419,441     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   1,492  $566.62    $845,402     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   1,160  $549.94    $637,925     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   333  $499.87    $166,457     Option 
    LEONARD KEITH R  director  director 
  Common Stock   1,545  $271.48    $419,441     Option 
    LEONARD KEITH R  director  director 
  Non-Qualified Stock Option (right to buy)   1,545  $271.48    $419,441     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   333  $499.87    $166,457     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   227  $592.78    $134,562     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   31,875  $113.73    $3,625,144     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   31,875  $113.73    $3,625,144     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   22,233  $576.56    $12,818,681     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   4,250  $119.06    $506,018     Sale 
    JOHNSON AMAL M  director  director 
  Common Stock   4,250  $119.06    $506,018     Option 
    JOHNSON AMAL M  director  director 
  Non-Qualified Stock Option (right to buy)   4,250  $119.06    $506,018     Sale 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   400  $562.3    $224,920     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   7,500  $113.73    $852,975     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   7,500  $113.73    $852,975     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,250  $376.02    $846,040     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   750  $562.3    $421,725     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   3,000  $438.11    $1,314,336     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   7,500  $113.73    $852,975     Option 
    LEVY ALAN J  director  director 
  Common Stock   1,950  $193.08    $376,506     Option 
    LEVY ALAN J  director  director 
  Non-Qualified Stock Option (right to buy)   1,950  $193.08    $376,506     Sale 
    LEVY ALAN J  director  director 
  Common Stock   1,950  $193.08    $376,506     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   332  $472.34    $156,818     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   72  $570.33    $41,064     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   72  $570.33    $41,064     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   451  $491.94    $221,865     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   225  $503.38    $113,261     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   130  $449.22    $58,398     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   36  $584.63    $21,047     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   31,875  $113.73    $3,625,144     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   31,875  $113.73    $3,625,144     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   22,377  $582.12    $13,026,077     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   11,140  $535.63    $5,966,963     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   10,835  $528.35    $5,724,618     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   2,071  $589.34    $1,220,529     Sale 
    RUBASH MARK J  director  director 
  Common Stock   1,000  $193.08    $193,080     Option 
    RUBASH MARK J  director  director 
  Common Stock   1,000  $193.08    $193,080