Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   240  $267.03    $64,087     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   90  $179.7    $16,173     Sale 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   584  $371.55    $216,985     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Non-Qualified Stock Option (right to buy)   188  $290.33    $54,582     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Non-Qualified Stock Option (right to buy)   188  $208.9    $39,273     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Non-Qualified Stock Option (right to buy)   240  $267.03    $64,087     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Non-Qualified Stock Option (right to buy)   792  $296.51    $234,834     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Non-Qualified Stock Option (right to buy)   90  $179.7    $16,173     Option 
    RUBASH MARK J  director  director 
  Common Stock   569  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    NACHTSHEIM JAMI K  director  director 
  Common Stock   569  N/A   N/A      Option 
    NACHTSHEIM JAMI K  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    KOLLI SREELAKSHMI  director  director 
  Common Stock   240  N/A   N/A      Option 
    KOLLI SREELAKSHMI  director  director 
  Restricted Stock Units   240  N/A   N/A      Option 
    KANIA DON R  director  director 
  Common Stock   569  N/A   N/A      Option 
    KANIA DON R  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Common Stock   569  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    LADD AMY L  director  director 
  Common Stock   569  N/A   N/A      Option 
    LADD AMY L  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Common Stock   569  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    BEERY JOSEPH C  director  director 
  Common Stock   569  N/A   N/A      Option 
    BEERY JOSEPH C  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Common Stock   804  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Restricted Stock Units   804  N/A   N/A      Option 
    REED MONICA P  director  director 
  Common Stock   569  N/A   N/A      Option 
    REED MONICA P  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Common Stock   569  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Restricted Stock Units   569  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Common Stock   2,000  $154.24    $308,474     Sale 
    LEVY ALAN J  director  director 
  Common Stock   2,000  $370.7    $741,398     Option 
    LEVY ALAN J  director  director 
  Non-Qualified Stock Option (right to buy)   2,000  $154.24    $308,474     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   2,818  $177.99    $501,567     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   2,500  $182.83    $457,083     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,818  $177.99    $501,567     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,500  $182.83    $457,083     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,500  $370.66    $926,645     Option 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Common Stock   612  $59.23    $36,248     Option 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Non-Qualified Stock Option (right to buy)   612  $59.23    $36,248     Sale 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Common Stock   612  $397.07    $243,007     Option 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Non-Qualified Stock Option (right to buy)   612  $59.23    $36,248     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   120  $229.39    $27,527     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   119  $304.67    $36,256     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   90  $179.7    $16,173     Sale 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   120  $390.16    $46,819     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   7,149  $347.42    $2,483,684     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   1,504  $290.33    $436,656     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   1,437  $304.67    $437,811     Option 
    DESANTIS ROBERT  officer: EVP & Chief Strategy & Corp Op  officer: EVP & Chief Strategy &.. 
  Common Stock   1,436  $229.39    $329,404