Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,200  $189.74    $417,421     Sale 
    FRIEDMAN MICHAEL A  director  director 
  Common Stock   996  $462.71    $460,859     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   2,200  $189.74    $417,421     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   119  $500    $59,500     Option 
    SMITH LONNIE M  director  director 
  Restricted Stock Units   450  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Common Stock   332  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Restricted Stock Units   332  N/A   N/A      Option 
    FRIEDMAN MICHAEL A  director  director 
  Common Stock   332  N/A   N/A      Option 
    NACHTSHEIM JAMI K  director  director 
  Common Stock   332  N/A   N/A      Option 
    FRIEDMAN MICHAEL A  director  director 
  Restricted Stock Units   332  N/A   N/A      Option 
    NACHTSHEIM JAMI K  director  director 
  Restricted Stock Units   332  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Common Stock   332  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Restricted Stock Units   332  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Restricted Stock Units   332  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Common Stock   332  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Common Stock   332  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Restricted Stock Units   332  N/A   N/A      Option 
    SMITH LONNIE M  director  director 
  Common Stock   450  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Common Stock   391  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Restricted Stock Units   391  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,785  $456.68    $815,170     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   1,327  $424.97    $563,939     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   563  $551.79    $310,659     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   210  $546.56    $114,777     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   669  $550    $367,950     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   431  $550    $237,050     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   669  $550    $367,950     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   1,410  $546.56    $770,652     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   1,339  $546.61    $731,907     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   59  $544    $32,096     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,799  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   3,987  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   5,974  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   2,799  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   4,711  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   4,711  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   5,974  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   3,987  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   178  $450.83    $80,248     Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Restricted Stock Units   750  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   843  N/A   N/A      Option 
    ANDERSEN REITER KARA  officer: Sr VP General Counsel & CCO  officer: Sr VP General Counsel .. 
  Common Stock   750  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   4,711  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Restricted Stock Units   4,711  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   1,766  $300.56    $530,782     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   2,542  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   763  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   3,918  $274.25    $1,074,512     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   3,918  $274.25    $1,074,512     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   763  N/A   N/A