Sale 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   5,000  $341.19    $1,705,950     Option 
    SMITH LONNIE M  director  director 
  Non-Qualified Stock Option (right to buy)   20,000  $423.94    $8,478,880     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Non-Qualified Stock Option (right to buy)   2,800  $303.27    $849,156     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   5,000  $490.07    $2,450,350     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   12,672  $544.62    $6,901,399     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   2,800  $303.27    $849,156     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   5,000  $490.07    $2,450,350     Option 
    SMITH LONNIE M  director  director 
  Common Stock   20,000  $423.94    $8,478,880     Sale 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   2,800  $303.27    $849,156     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   5,000  $490.07    $2,450,350     Sale 
    LEVY ALAN J  director  director 
  Common Stock   417  $495.41    $206,587     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   17,840  $492.16    $8,780,063     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   25,000  $106.69    $2,667,250     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   25,000  $106.69    $2,667,250     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   375  $383.73    $143,899     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   375  $383.73    $143,899     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   375  $383.73    $143,899     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   2,000  $488.68    $977,360     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   1,000  $334.3    $334,300     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   1,000  $334.3    $334,300     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   1,000  $334.3    $334,300     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   13,488  $403.26    $5,439,130     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   13,488  $403.26    $5,439,130     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   10,824  $503.47    $5,449,603     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   261  $504.54    $131,685     Sale 
    HALVORSON ERIC H  director  director 
  Common Stock   200  $506.15    $101,230     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   10,000  $107.27    $1,072,700     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   10,000  $107.27    $1,072,700     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Non-Qualified Stock Option (right to buy)   15,000  $341.19    $5,117,850     Option 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   15,000  $341.19    $5,117,850     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   10,000  $107.27    $1,072,700     Sale 
    MCNAMARA JEROME J  officer: Sr Advisor - Commercial Ops  officer: Sr Advisor - Commercia.. 
  Common Stock   15,000  $341.19    $5,117,850     Option 
    LEVY ALAN J  director  director 
  Common Stock   417  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Restricted Stock Units   354  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Restricted Stock Units   417  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Common Stock   354  N/A   N/A      Option 
    HALVORSON ERIC H  director  director 
  Common Stock   354  N/A   N/A      Option 
    HALVORSON ERIC H  director  director 
  Restricted Stock Units   354  N/A   N/A      Option 
    SMITH LONNIE M  director  director 
  Restricted Stock Units   500  N/A   N/A      Option 
    SMITH LONNIE M  director  director 
  Non-Qualified Stock Option (right to buy)   20,000  $303.27    $6,065,400     Option 
    BARRATT CRAIG H  director  director 
  Restricted Stock Units   354  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Common Stock   354  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Restricted Stock Units   354  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Common Stock   354  N/A   N/A      Option 
    SMITH LONNIE M  director  director 
  Common Stock   20,500  $151.64    $3,108,518     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   20,000  $303.27    $6,065,400     Option 
    STALK GEORGE JR  director  director 
  Restricted Stock Units   354  N/A   N/A      Option 
    STALK GEORGE JR  director  director 
  Common Stock   354  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,375  $421.09    $578,992     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   1,375  $421.09    $578,992