Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   1,500  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   3,375  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   1,593  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   1,500  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Restricted Stock Units   1,593  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   843  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   2,437  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   843  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,500  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   475  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   1,500  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   1,251  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   2,001  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   1,251  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   1,500  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   2,001  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   1,000  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   750  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Restricted Stock Units   750  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   1,000  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Restricted Stock Units   1,500  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   475  N/A   N/A      Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   7,724  $414.5    $3,201,606     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   7,500  $111.43    $835,748     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   7,500  $111.43    $835,748     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   60,000  $35.76    $2,145,420     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   60,000  $35.76    $2,145,420     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   28,525  $414.5    $11,823,641     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   7,500  $111.43    $835,748     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   699  $381.8    $266,875     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   262  $171.33    $44,889     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   18,000  $428.68    $7,716,312     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   262  $171.33    $44,889     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   262  $171.33    $44,889     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   574  $428.57    $246,000     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   118  $428    $50,504     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   4,393  $361.2    $1,586,760     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   777  $347.51    $270,012     Option 
    RUBASH MARK J  director  director 
  Common Stock   2,000  $161.27    $322,534     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   536  $400    $214,400     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,689  $396.59    $669,834     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   4,393  $361.2    $1,586,760     Sale 
    RUBASH MARK J  director  director 
  Common Stock   2,000  $161.27    $322,534     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   910  $326.01    $296,668     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   6,000  $161.27    $967,602     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   3,000  $121.99    $365,979     Option 
    JOHNSON AMAL M  director  director 
  Non-Qualified Stock Option (right to buy)   3,000  $121.99    $365,979     Sale 
    JOHNSON AMAL M  director  director 
  Common Stock   3,000  $121.99    $365,979     Sale 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   3,000  $111.43    $334,299     Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Non-Qualified Stock Option (right to buy)   3,000  $111.43    $334,299