Sale 
    RUBASH MARK J  director  director 
  Common Stock   4,300  $297.93    $1,281,086     Option 
    RUBASH MARK J  director  director 
  Common Stock   460  $171.07    $78,694     Option 
    RUBASH MARK J  director  director 
  Common Stock   349  $71.32    $24,892     Option 
    RUBASH MARK J  director  director 
  Common Stock   299  $154.24    $46,117     Option 
    RUBASH MARK J  director  director 
  Common Stock   235  $172.59    $40,559     Option 
    RUBASH MARK J  director  director 
  Common Stock   230  $171.07    $39,347     Option 
    RUBASH MARK J  director  director 
  Common Stock   173  $71.32    $12,339     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   2,184  $245.6    $536,390     Option 
    BARRATT CRAIG H  director  director 
  Non-Qualified Stock Option (right to buy)   2,000  $41.26    $82,516     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   1,118  $297.92    $333,071     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Non-Qualified Stock Option (right to buy)   2,444  $208.9    $510,552     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $174.26    $1,045,542     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   927  $90.49    $83,888     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   6,000  $300    $1,800,006     Sale 
    WIDMAN FREDRIK  officer: VP Corporate Controller  officer: VP Corporate Controller 
  Common Stock   630  $297.87    $187,658     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   927  $90.49    $83,888     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   2,000  $166.62    $333,246     Sale 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   1,196  $297.91    $356,303     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   598  $154.24    $92,234     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   1,086  $242.34    $263,178     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   472  $172.59    $81,464     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   927  $90.49    $83,888     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   460  $171.07    $78,694     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   598  $154.24    $92,234     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   546  $178.84    $97,648     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   173  $71.32    $12,339     Sale 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   1,167  $297.9    $347,645     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   472  $172.59    $81,464     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   463  $90.49    $41,899     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   460  $171.07    $78,694     Sale 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   3,803  $297.95    $1,133,096     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   349  $71.32    $24,892     Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Common Stock   2,444  $208.9    $510,552     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   598  $154.24    $92,234     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   472  $172.59    $81,464     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   460  $171.07    $78,694     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   299  $154.24    $46,117     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   349  $71.32    $24,892     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   235  $172.59    $40,559     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   230  $171.07    $39,347     Option 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   2,000  $166.62    $333,246     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   349  $71.32    $24,892     Option 
    ROSA DAVID J.  officer: EVP Chief Strategy & Growth Of  officer: EVP Chief Strategy & G.. 
  Common Stock   54,000  $42.64    $2,302,398     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   505  $300    $151,500     Sale 
    CURET MYRIAM  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   1,253  $228.47    $286,273     Option 
    SAMATH JAMIE  officer: Chief Financial Officer  officer: Chief Financial Officer 
  Common Stock   1,257  N/A   N/A      Option 
    SAMATH JAMIE  officer: Chief Financial Officer  officer: Chief Financial Officer 
  Common Stock   752  N/A   N/A      Option 
    CHARLTON HENRY L  officer: Senior Vice President & Chief  officer: Senior Vice President .. 
  Common Stock   1,449  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP Chief Strategy & Growth Of  officer: EVP Chief Strategy & G.. 
  Restricted Stock Units   1,504  N/A   N/A      Option 
    DESANTIS ROBERT  officer: EVP & Chief Product Officer  officer: EVP & Chief Product Of.. 
  Restricted Stock Units   2,175  N/A   N/A