Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Restricted Stock Units   521  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   521  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   625  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Restricted Stock Units   500  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   521  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   260  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   521  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   625  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   260  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   7,750  $445.98    $3,456,368     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   521  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Non-Qualified Stock Option (right to buy)   8,750  $646.64    $5,658,100     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   521  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   417  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   867  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Restricted Stock Units   758  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   2,000  $303.27    $606,540     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   704  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   867  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Restricted Stock Units   569  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   244  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   758  N/A   N/A      Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,000  $303.27    $606,540     Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   569  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   244  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   433  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   758  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,704  $151.64    $410,021     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   433  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   758  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   813  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   813  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Restricted Stock Units   1,125  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Restricted Stock Units   625  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   500  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   813  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   532  N/A   N/A      Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Restricted Stock Units   532  N/A   N/A      Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Restricted Stock Units   813  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Restricted Stock Units   282  N/A   N/A      Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   500  N/A   N/A      Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   1,125  N/A   N/A      Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   625  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   282  N/A   N/A      Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   1,000  $334.3    $334,300     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   1,000  $334.3    $334,300     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   1,000  $334.3    $334,300     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   2,000  $107.27    $214,540     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,000  $303.27    $606,540     Sale 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   2,000  $107.27    $214,540