Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Non-Qualified Stock Option (right to buy)   2,000  $107.27    $214,540     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   2,000  $303.27    $606,540     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   2,000  $700    $1,400,000     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,000  $303.27    $606,540     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   5,797  $574.77    $3,331,924     Sale 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Common Stock   3,000  $695    $2,085,000     Option 
    MORALES COLIN  officer: GM & SVP Secondary Mkt Equip &  officer: GM & SVP Secondary Mkt.. 
  Non-Qualified Stock Option (right to buy)   5,797  $574.77    $3,331,924     Option 
    LEONARD KEITH R  director  director 
  Common Stock   100  N/A   N/A      Sale 
    SMITH LONNIE M  director  director 
  Common Stock   1,000  $684.38    $684,380     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   3,000  $288.5    $865,500     Sale 
    RUBASH MARK J  director  director 
  Common Stock   3,000  $288.5    $865,500     Option 
    RUBASH MARK J  director  director 
  Common Stock   3,000  $288.5    $865,500     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   1,000  $650    $650,000     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   7,200  $303.27    $2,183,544     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Non-Qualified Stock Option (right to buy)   7,200  $303.27    $2,183,544     Sale 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   7,200  $303.27    $2,183,544     Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   750  $334.3    $250,725     Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Non-Qualified Stock Option (right to buy)   2,250  $334.3    $752,175     Sale 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   750  $334.3    $250,725     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   275  $646.5    $177,787     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   13,515  $680.68    $9,199,431     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   17,500  $112.66    $1,971,550     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   17,500  $112.66    $1,971,550     Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   750  $334.3    $250,725     Sale 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   750  $334.3    $250,725     Option 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Non-Qualified Stock Option (right to buy)   3,000  $334.3    $1,002,900     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   375  N/A   N/A      Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Restricted Stock Units   375  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Non-Qualified Stock Option (right to buy)   3,188  $365.98    $1,166,744     Option 
    LEVY ALAN J  director  director 
  Common Stock   3,188  $365.98    $1,166,744     Sale 
    LEVY ALAN J  director  director 
  Common Stock   3,188  $365.98    $1,166,744     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   17,500  $112.66    $1,971,550     Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Non-Qualified Stock Option (right to buy)   17,500  $112.66    $1,971,550     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   13,400  $698    $9,353,187     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   4,250  $564.22    $2,397,914     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   5,000  $303.27    $1,516,350     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Non-Qualified Stock Option (right to buy)   4,250  $564.22    $2,397,914     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   5,000  $303.27    $1,516,350     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   3,000  $684.34    $2,053,017     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   5,000  $303.27    $1,516,350     Option 
    FRIEDMAN MICHAEL A  director  director 
  Restricted Stock Units   325  N/A   N/A      Option 
    FRIEDMAN MICHAEL A  director  director 
  Common Stock   325  N/A   N/A      Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   600  $630.96    $378,576     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   375  $383.73    $143,899     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   13,406  $590.44    $7,915,398     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   8,336  $569.89    $4,750,578     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   2,000  $627.23    $1,254,454     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   530  $629.36    $333,560     Option 
    STALK GEORGE JR  director  director 
  Common Stock   7,644  $566.4    $4,329,539     Sale 
    STALK GEORGE JR  director  director 
  Common Stock   1,212  $357.19    $432,914