Option 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   25,000  $303.27    $7,581,750     Option 
    LEVY ALAN J  director  director 
  Common Stock   1,001  $584.43    $585,014     Option 
    LEVY ALAN J  director  director 
  Non-Qualified Stock Option (right to buy)   1,001  $584.43    $585,014     Sale 
    LEVY ALAN J  director  director 
  Common Stock   313  $811.67    $254,053     Sale 
    GUTHART GARY S  director, officer: President & CEO  director, officer: President & .. 
  Common Stock   18,775  $810.33    $15,214,002     Sale 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   5,000  $107.27    $536,350     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Non-Qualified Stock Option (right to buy)   5,000  $107.27    $536,350     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   5,000  $107.27    $536,350     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   327  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Restricted Stock Units   327  N/A   N/A      Option 
    FRIEDMAN MICHAEL A  director  director 
  Restricted Stock Units   327  N/A   N/A      Option 
    BARRATT CRAIG H  director  director 
  Common Stock   327  N/A   N/A      Option 
    LEONARD KEITH R  director  director 
  Common Stock   327  N/A   N/A      Option 
    FRIEDMAN MICHAEL A  director  director 
  Common Stock   327  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Common Stock   385  $817    $314,545     Option 
    BARRATT CRAIG H  director  director 
  Restricted Stock Units   327  N/A   N/A      Option 
    STALK GEORGE JR  director  director 
  Restricted Stock Units   327  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Restricted Stock Units   327  N/A   N/A      Option 
    LEVY ALAN J  director  director 
  Restricted Stock Units   385  $817    $314,545     Option 
    SMITH LONNIE M  director  director 
  Restricted Stock Units   443  N/A   N/A      Option 
    STALK GEORGE JR  director  director 
  Common Stock   327  N/A   N/A      Option 
    RUBASH MARK J  director  director 
  Common Stock   327  N/A   N/A      Option 
    SMITH LONNIE M  director  director 
  Common Stock   443  N/A   N/A      Option 
    JOHNSON AMAL M  director  director 
  Restricted Stock Units   327  N/A   N/A      Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Non-Qualified Stock Option (right to buy)   4,268  $658.43    $2,810,192     Sale 
    LEVY ALAN J  director  director 
  Common Stock   313  $750    $234,750     Option 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   3,910  $627.91    $2,455,128     Option 
    RUBASH MARK J  director  director 
  Non-Qualified Stock Option (right to buy)   2,000  $288.5    $577,000     Option 
    JOHNSON AMAL M  director  director 
  Non-Qualified Stock Option (right to buy)   1,000  $365.98    $365,980     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   4,250  $526.64    $2,238,199     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   2,000  $750    $1,500,000     Sale 
    SAMATH JAMIE  officer: SVP of Finance  officer: SVP of Finance 
  Common Stock   358  $750    $268,500     Option 
    JOHNSON AMAL M  director  director 
  Common Stock   1,000  $365.98    $365,980     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Non-Qualified Stock Option (right to buy)   5,000  $107.27    $536,350     Option 
    LEVY ALAN J  director  director 
  Non-Qualified Stock Option (right to buy)   1,001  $553.6    $554,149     Sale 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   5,000  $107.27    $536,350     Option 
    ROSA DAVID J.  officer: EVP and Chief Business Officer  officer: EVP and Chief Business.. 
  Common Stock   5,000  $107.27    $536,350     Option 
    RUBASH MARK J  director  director 
  Common Stock   2,000  $288.5    $577,000     Sale 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Common Stock   2,250  $750    $1,687,500     Sale 
    JOHNSON AMAL M  director  director 
  Common Stock   1,000  $365.98    $365,980     Sale 
    RUBASH MARK J  director  director 
  Common Stock   2,000  $288.5    $577,000     Option 
    LEVY ALAN J  director  director 
  Common Stock   1,001  $553.6    $554,149     Option 
    MOHR MARSHALL  officer: Executive VP & CFO  officer: Executive VP & CFO 
  Non-Qualified Stock Option (right to buy)   4,250  $526.64    $2,238,199     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Non-Qualified Stock Option (right to buy)   2,577  $648.53    $1,671,270     Sale 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   1,521  $736.8    $1,120,673     Option 
    BROGNA SALVATORE  officer: EVP & Chief Operating Officer  officer: EVP & Chief Operating .. 
  Common Stock   3,802  $666.19    $2,532,839     Sale 
    SMITH LONNIE M  director  director 
  Common Stock   35  $736.2    $25,767     Sale 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Common Stock   222  $729.8    $162,016     Option 
    MYRIAM CURET  officer: EVP & Chief Medical Officer  officer: EVP & Chief Medical Of.. 
  Restricted Stock Units   417  N/A   N/A      Sale 
    MELTZER MARK J  officer: SVP General Counsel & CCO  officer: SVP General Counsel & .. 
  Common Stock   1,500  $334.3    $501,450